pay close attention to the instructions above!!!
8 Pages (does not include reference or title page)
References should be taken from the CDC, NIH, etc. or the peer reviewed scientific literature
All of the following must be included in the paper:
The paper will be about Heart Disease.
1.Describe the pathophysiology of heart disease – What is the natural history of the disease, the spectrum of disease/pathology the disease? Is the disease characterized by inflammation?
etc? Is it an infectious and/or chronic disease? If so what is the agent, its reservoir, mode of transmission
2.What public health statistics are available on incidence rates/mortality rates for this disease? What is the
prevalence of the disease, case fatality, YPLL, etc?
3.What is the descriptive epidemiology of the disease? How does the disease vary by aspects of person?
(age, race and sex), place (geography) and time?
4.What is the analytic epidemiology of the disease? What epidemiological studies have been done to
characterize risk factors for the disease? Are there modifiable risk factors (e.g. smoking, diet) or non-
modifiable risk factors (e.g. Genetics)? What are the relative risks/odds ratios for these risk factors in
terms of direction and magnitude? Have previous studies evaluated confounding and/or effect
modification? Are previous findings statistically significant? Critically review this literature.
5.Are there effective screening tests for the disease? What are the sensitivity and specificity of these
screening tests? What is the positive predictive value?
6.What are the prospects for the prevention (primary, secondary, tertiary) of the disease through traditional
means (e.g. Vaccination) or more recent innovations such as smoking cessation programs?
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